A 62 year old female patient presented to us in October 2015 with a painful left breast lump which had grown progressively in size over the past 8 months. She had undergone a surgical resection for a ...See details
Radiologist with focus on breast and urogenital imaging. Interpreted all breast imaging studies (mammography, US, CEUS, ABUS, MRI), pelvic MRI, whole-body MRI. Performed all breast procedures (stereot...
a case of Chronic lymphocytic leukemia (CLL) with associated hypersplenism, that was referred to us for partial splenic embolization (PSE) because the patient was not a surgical candidate for splenect...See details
Questions and Answers:
1. The most common site of intracranial calcifications in the pediatric population is:
b. Periventricular region
c. Pineal gland
e. Falx cerebri
Answer: c. In the pediatric population, they are typically seen in the pineal gland and choroid plexus. Pineal calcifications <1cm, appear as dots and tend to be benign in 40% of individuals less than 20 years old. Whereas pineal calcifications >1cm in patients younger than 9 years should be regarded as pathologic and warrant further investigation.
2. A blush-like pattern calcifications in the bilateral basal ganglia in a child is typically seen in:
a. Tuberous sclerosis
b. Raine syndrome
c. Krabbe’s disease
d. Sturge-Weber syndrome
Answer: c. Krabbe’s disease is an autosomal recessive demyelinating disorder affecting infants due to galactocerebroside b-galactosidase deficiency leading to accumulation of abnormal lipids. A symmetrical blush-like pattern of calcifications in the bilateral basal ganglia is characteristic.
3. A 3 day-old boy was admitted to the neonatal intensive care unit after an episode of tonic-clonic seizure. His mother denied prenatal care. Non-contrast CT was showed both sub-ependymal and periventricular calcifications with cerebral volume loss. What is the most likely diagnosis?
a. Tuberous sclerosis
b. Congenital CMV
c. Congenital hypothyroidism
e. Hypoglycemia-induced seizure
Answer: b. Congenital Cytomegalovirus (CMV): Incidence is 0.2-2.4% of live births. Intracranial calcifications are seen in 77% of those with imaging abnormalities typically in the sub-ependymal and periventricular regions of the brain along with brain atrophy.
4. Among all the intra-axial brain tumors, which of the following is mostly associated with intracranial calcifications?
b. Pilocytic astrocytoma
c. Dysembryonic neuroectodermal tumors
Answer: a. Oligodendrogliomas exhibit the highest frequency of calcifications (up to 90%). Calcifications can be scattered dots or clumped together to form large nodules, located centrally or peripherally and frequently in the frontal lobes.
5. A 50-year-old female patient presented with dry cough, fatigue, and shortness of breath. On physical exam she has tender reddish bumps on the skin. Review of the systems revealed seizures and depression. CXR showed enlarged hilar lymph nodes and CT scan of the brain showed small calcified masses in the leptomeninges and periventricular white matter. What is the most likely diagnosis?
d. Chronic lead toxicity
Answer: e. Sarcoidosis affects many organs including the CNS, lungs and skin. On non-contrast CT scan of the brain, small calcified granulomas can be seen in the leptomeninges, periventricular white matter, pons, hypothalamus, pituitary stalk, and optic chiasm with varying degrees of edema.
CASE: A three-year-old male presented with a one-week history of fussiness, lack of appetite, intermittent nausea and vomiting, and a one-day history of fever. Five weeks prior, he had a VP shunt p...See details
Case of persistent trigeminal artery associated with a cavernous carotid aneurysm. Join the debate- incidental or increased incidence?
We report a case of an indwelling inferior vena cava (IVC) filter that penetrated the IVC wall after Whipple’s pancreatico-duodenectomy procedure performed in a patient with ampullary carcinoma, res...See details
Superior Vena Cava (SVC) occlusion causing SVC Syndrome is most commonly caused by malignancy, but there are several benign etiologies. With the increased use of central venous catheters since the 19...See details
Origin of the anomalous left coronary artery from the pulmonary artery ( ALCAPA ) Also known as Bland -White -Garland syndrome , is an uncommon congenital heart disease . Approximately 90 % of pati...See details