Characteristic Lung Findings in Antisynthetase Syndrome

Posted By Nicholas Broadbent
Characteristic Lung Findings in Antisynthetase Syndrome

Characteristic NSIP with OP seen on HRCT in a 66 year old female with antisynthetase syndrome.

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  • Nicholas Broadbent 2014-08-01 18:57:36

    I failed to mention that a lung biopsy was also performed.


  • Nicholas Broadbent 2014-08-01 18:54:59

    Dr. Talanow, this patient underwent a rheumatologic workup which included an antibody panel for antisynthetase syndrome. This particular patient was positive for PL-12 which, along with the characteristic clinical findings, confirmed the suspected diagnosis.


  • Roland Talanow 2014-07-23 15:14:38

    What kind of workup was done to confirm that diagnosis?


  • Nicholas Broadbent 2014-07-12 19:49:06

    Hi Tony, thanks for the comment. There are predominantly basilar, reticular and ground-glass opacities, accompanied by a loss of lung volume, traction bronchiectasis, and scattered peribronchovascular areas of consolidation. This is suggestive of an NSIP with features OP. These findings are noted to be quite typical of patients with ILD associated with antisynthetase syndrome. Of course these findings would be supported with clinical dx and rheumatologic workup.


  • Tony 2014-07-12 19:09:21

    Interesting case. Could you explain what the characteristic findings are?

    Based on that image, several DDs are possible.

    Thank you.