Spinal Melanocytoma to Melanoma: A Case Report

Posted By Daphne Scarpelli
Spinal Melanocytoma to Melanoma: A Case Report

Gender, Age

Female, 57


Spinal Melanoctyoma transformed to Metastatic primary leptomeningeal melanoma (GNAQ Q209P)


A year from post-resection, a 57-year-old Caucasian female with a history of SMM and had undergone subtotal resection (STR) exhibited local recurrence and was treated with stereotactic body radiotherapy (SBRT) to a dose of 45 Gy in 5 fractions. While under radiotherapy, routine MRI revealed a lesion at the C7-T1 level, resulting in C7/T1 laminectomy. She was additionally treated with stereotactic radiosurgery (SRS) to 20 Gy for a tumor nodule at the right IAC. Pathological findings revealed melanoma and a GNAQ Q209P mutation. The patient continues treatment with Pembrolizumab. Her most recent imaging indicates the progression of metastatic disease throughout the spine (Figure 1).  

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